CoverGraf®

CoverGraf^®

Tacrolimus

CoverGraf® is a quality immunosuppressant manufactured in a state-of-the-art facility complying with FDA and WHO-GMP norms. Tacrolimus is the mainstay of solid-organ transplantation and has demonstrated lower acute-rejection rates and better graft survival in many studies over the past decade.

Indication

CoverGraf® is indicated for the prophylaxis of organ rejection in patients receiving allogeneic kidney, liver or heart transplants, in combination with other immunosuppressants.

Mechanism of action

Tacrolimus is a macrolide belonging to the class of calcineurin inhibitors (CNIs), which form the cornerstone of immunosuppressive therapy in solid-organ transplantation. It binds FKBP-12 to inhibit calcineurin phosphatase, blocking T-cell activation and the transcription of early cytokines (IL-2, IFN-γ) that drive the rejection cascade. Studies also support its use in glomerular diseases at the discretion of treating specialists.

Strengths

•0.5 mg hard gelatin capsule
•1 mg hard gelatin capsule

Composition

CoverGraf® 0.5 - each hard gelatin capsule contains Tacrolimus 0.5 mg I.P. CoverGraf® 1 - each hard gelatin capsule contains Tacrolimus 1 mg I.P.

Presentation

Aluminium foil pack of 10 capsules of CoverGraf® 0.5 in one strip, six strips in a box. Aluminium foil pack of 10 capsules of CoverGraf® 1 in one strip, six strips in a box.

For Healthcare Professionals

Kidney transplant: 0.1–0.2 mg/kg/day divided in two doses, every 12 hours. Liver transplant: 0.1–0.15 mg/kg/day. Heart transplant: 0.075 mg/kg/day. Dosage depends on concomitant immunosuppressants, corticosteroids and induction agents. Schematic monitoring of whole-blood trough levels is mandatory post-transplant; targets vary by post-transplant time-point and centre protocol.

This section is intended for use by registered medical practitioners only. All clinical decisions remain the prescriber's responsibility and should be informed by the current approved product label.

Notes for patients & caregivers

Take at the same times every day, on an empty stomach (1 hour before or 2 hours after food) and at consistent intervals from any other medicines. Avoid grapefruit and grapefruit juice. Never skip or double-dose without speaking to your transplant team.

These notes are for general awareness only and are not a substitute for medical advice. Please follow your treating physician's instructions and the directions on the dispensed product.

Storage

Store below 25°C. Protect from moisture. Keep in original packaging until use.

Important

• CoverGraf® is a prescription medicine. It must only be used on the advice of a registered medical practitioner.
• Always refer to the current approved Indian product label / package insert for definitive prescribing information.
• If you experience any quality or safety concern, please contact us or write to info@vyapitus.com.